SPOREs

Breast

Breast SPORE

The Dana-Farber/Harvard SPORE in Breast Cancer is currently in its eighth year of funding. The SPORE features six research projects, six core resources, a developmental project program, a career development program and several funded Avon Progress for Patients supplements. The SPORE is an integral component of the DF/HCC Program in Breast Cancer and represents a significant translational research collaboration in breast cancer.

Breast SPORE Participating Institutions
Broad Institute	Harvard Medical School
Beth-Israel Deaconess Medical Center	Harvard School of Public Health
Brigham and Women's Hospital	Harvard University
Children's Hospital Boston	Massachusetts General Hospital
Dana-Farber Cancer Institute	Whitehead Institute
Breast SPORE Collaborating Researcher's Institutions
Fred Hutchinson Cancer Research Center

Breast SPORE Projects

Projects in the Breast SPORE fall into two broad categories as summarized below:

Projects starting with treatments

Project 1 — Biology and treatment of BRCA1 mutant and sporadic basal-like cancers
Project 2 — Targeted combinations for HER2 – positive breast cancer
Project 3 — Role of coregulators in response to aromatase inhibitors

Projects starting with tissues

Project 4 — Biology of metastasis in breast cancer patients
Project 5 — Stromal-epithelial interactions and implications for risk, prevention and treatment
Project 6 — Variation in receptor tyrosine kinases and breast cancer risk

Core Resources in the Breast SPORE

The Cores deliver the benefits of efficiencies to the Projects and the respective Cores. By centralizing these specific functions and responsibilities, it allows the SPORE to leverage its resources.

Core 1 — Tissue and Pathology provides a range of tissues and services
Core 2 — Clinical Studies manages the interface between research and patients (recruitment, consent, and registration)
Core 3 — Cohort Studies and Databases
Core 4 — Biostatistics provide statistical consultation to SPORE investigators
Core 5 — Genomic Data and Bioinformatics manages large genomic data sets and provides initital consultation to investigators seeking analytical help
Core 6 — Communications, Planning and Administration works to improve the SPORE by evaluating, planning, and modifying our research to maximize our impact on breast cancer

SPORE Updates

04-24-08 New cell death program solves mystery of bird’s eye cells

03-19-08 DF/HCC Nodal Award Program 2008

02-15-08 BOSS presents: Controversies and Challenges in HER2 Testing